Q13546

Background

Protein Name
Receptor-interacting serine/threonine-protein kinase 1
Gene Name
RIPK1
Organism
Homo sapiens

Annotations

Function
Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex.

Mapping Statistics

Site Maximum Consensus Site Population Minimum Consensus Site Population Median Consensus Site Population
MPP 14 2 6.0
DFG 6 4 5.0
PIF 27 6 13.0
EDI 14 5 9.5
MT3 21 3 14.5
AAS 13 3 6.5
CMP 15 15 15.0
ATP 18 2 10.0

Mapping Results

PDB ID Maximum Consensus Site Population
MPP site DFG site PIF site DRS site DEF site EDI site MT3 site AAS site LBP site CMP site PDIG site ATP site PMP site
Total Druggable Structures per Site 0 0 2 0 0 0 2 0 0 0 0 1 0
4NEU 14 6 0 0 0 14 5 11 0 0 0 18 0
4ITI 0 0 27 0 0 0 0 13 0 0 0 2 0
4ITJ 0 0 16 0 0 0 7 0 0 0 0 0 0
5HX6 7 0 13 0 0 0 17 3 0 0 0 0 0
4ITH 5 0 13 0 0 5 21 0 0 15 0 4 0
AFQ13546 0 0 0 0 0 0 0 0 0 0 0 0 0