- Protein Name
- Bone morphogenetic protein receptor type-2
- Gene Name
- BMPR2
- Organism
-
Homo sapiens
- Function
- On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MPP |
2 |
2 |
2.0 |
| DFG |
20 |
3 |
17.0 |
| EDI |
17 |
17 |
17.0 |
| MT3 |
2 |
2 |
2.0 |
| AAS |
2 |
2 |
2.0 |
| ATP |
16 |
2 |
6.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
0 |
2 |
0 |
0 |
0 |
1 |
0 |
0 |
0 |
0 |
0 |
1 |
0 |
|
AFQ13873
|
0 |
20 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
3G2F
|
2 |
18 |
0 |
0 |
0 |
17 |
2 |
2 |
0 |
0 |
0 |
16 |
0 |