Q14004

Background

Protein Name
Cyclin-dependent kinase 13
Gene Name
CDK13
Organism
Homo sapiens

Annotations

Function
Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef.

Mapping Statistics

Site Maximum Consensus Site Population Minimum Consensus Site Population Median Consensus Site Population
EDI 7 7 7.0
PIF 18 18 18.0
ATP 21 3 12.0
MPP 10 10 10.0
DFG 16 4 10.0
LBP 17 17 17.0
PDIG 21 21 21.0

Mapping Results

PDB ID Maximum Consensus Site Population
EDI site MT3 site PIF site ATP site DEF site DRS site AAS site MPP site DFG site LBP site CMP site PDIG site PMP site
Total Druggable Structures per Site 0 0 1 1 0 0 0 0 1 1 0 1 0
5EFQ 7 0 18 21 0 0 0 10 4 17 0 21 0
AFQ14004 0 0 0 0 0 0 0 0 16 0 0 0 0