- Protein Name
- Cyclin-dependent kinase 13
- Gene Name
- CDK13
- Organism
-
Homo sapiens
- Function
- Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MPP |
10 |
10 |
10.0 |
| DFG |
16 |
4 |
10.0 |
| PIF |
18 |
18 |
18.0 |
| EDI |
7 |
7 |
7.0 |
| LBP |
17 |
17 |
17.0 |
| PDIG |
21 |
21 |
21.0 |
| ATP |
21 |
3 |
12.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
0 |
1 |
1 |
0 |
0 |
0 |
0 |
0 |
1 |
0 |
1 |
1 |
0 |
|
5EFQ
|
10 |
4 |
18 |
0 |
0 |
7 |
0 |
0 |
17 |
0 |
21 |
21 |
0 |
|
AFQ14004
|
0 |
16 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |