- Protein Name
- Protein-tyrosine kinase 2-beta
- Gene Name
- PTK2B
- Organism
-
Homo sapiens
- Function
- Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T-cells, and contributes to the regulation of T-cell responses. Promotes osteoclastic bone resorption; this requires both PTK2B/PYK2 and SRC. May inhibit differentiation and activity of osteoprogenitor cells. Functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors (GPCR), cytokine, chemokine and growth factor receptors, and mediates responses to cellular stress. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Promotes activation of NOS3. Regulates production of the cellular messenger cGMP. Promotes activation of the MAP kinase signaling cascade, including activation of MAPK1/ERK2, MAPK3/ERK1 and MAPK8/JNK1. Promotes activation of Rho family GTPases, such as RHOA and RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Acts as a scaffold, binding to both PDPK1 and SRC, thereby allowing SRC to phosphorylate PDPK1 at 'Tyr-9, 'Tyr-373', and 'Tyr-376'. Promotes phosphorylation of NMDA receptors by SRC family members, and thereby contributes to the regulation of NMDA receptor ion channel activity and intracellular Ca(2+) levels. May also regulate potassium ion transport by phosphorylation of potassium channel subunits. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ASAP1, NPHP1, KCNA2 and SHC1. Promotes phosphorylation of ASAP2, RHOU and PXN; this requires both SRC and PTK2/PYK2.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MPP |
26 |
2 |
10.0 |
| DFG |
4 |
2 |
3.0 |
| PIF |
19 |
14 |
16.5 |
| EDI |
3 |
3 |
3.0 |
| MT3 |
7 |
2 |
7.0 |
| AAS |
9 |
9 |
9.0 |
| PDIG |
22 |
2 |
10.5 |
| ATP |
17 |
3 |
8.5 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
3 |
0 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
4 |
2 |
0 |
|
3FZS
|
11 |
0 |
0 |
0 |
0 |
0 |
7 |
0 |
0 |
0 |
8 |
8 |
0 |
|
3FZP
|
14 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
20 |
11 |
0 |
|
3H3C
|
19 |
0 |
0 |
0 |
0 |
0 |
0 |
9 |
0 |
0 |
21 |
8 |
0 |
|
3FZO
|
10 |
0 |
14 |
0 |
0 |
3 |
0 |
0 |
0 |
0 |
20 |
9 |
0 |
|
4H1M
|
3 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
9 |
10 |
0 |
|
3ET7
|
5 |
2 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
2 |
17 |
0 |
|
3FZR
|
5 |
4 |
0 |
0 |
0 |
0 |
2 |
0 |
0 |
0 |
8 |
17 |
0 |
|
3FZT
|
12 |
0 |
0 |
0 |
0 |
0 |
7 |
0 |
0 |
0 |
6 |
4 |
0 |
|
3CC6
|
16 |
0 |
19 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
22 |
4 |
0 |
|
AFQ14289
|
26 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
4H1J
|
15 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
12 |
3 |
0 |