- Protein Name
- Maternal embryonic leucine zipper kinase
- Gene Name
- MELK
- Organism
-
Homo sapiens
- Function
- Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MPP |
23 |
4 |
11.5 |
| DFG |
16 |
2 |
9.0 |
| PIF |
19 |
19 |
19.0 |
| DRS |
21 |
3 |
14.0 |
| EDI |
18 |
3 |
13.0 |
| MT3 |
20 |
4 |
10.0 |
| AAS |
23 |
3 |
9.0 |
| CMP |
13 |
2 |
3.0 |
| PDIG |
31 |
11 |
17.0 |
| ATP |
30 |
2 |
13.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
11 |
1 |
1 |
2 |
0 |
3 |
2 |
1 |
0 |
0 |
12 |
12 |
0 |
|
4D2P
|
17 |
0 |
0 |
0 |
0 |
10 |
11 |
0 |
0 |
3 |
31 |
30 |
0 |
|
4UMT
|
16 |
0 |
0 |
0 |
0 |
16 |
15 |
0 |
0 |
13 |
20 |
26 |
0 |
|
4BL1
|
23 |
16 |
19 |
16 |
0 |
0 |
0 |
0 |
0 |
0 |
14 |
12 |
0 |
|
5IH9
|
15 |
10 |
0 |
0 |
0 |
11 |
0 |
0 |
0 |
0 |
19 |
21 |
0 |
|
4UMR
|
19 |
13 |
0 |
0 |
0 |
12 |
4 |
10 |
0 |
2 |
19 |
17 |
0 |
|
4BKY
|
19 |
0 |
0 |
21 |
0 |
0 |
6 |
14 |
0 |
0 |
0 |
14 |
0 |
|
4D2W
|
18 |
0 |
0 |
0 |
0 |
18 |
0 |
0 |
0 |
0 |
17 |
16 |
0 |
|
4UMQ
|
14 |
0 |
0 |
0 |
0 |
15 |
7 |
23 |
0 |
2 |
21 |
17 |
0 |
|
4UMP
|
19 |
3 |
0 |
0 |
0 |
16 |
0 |
6 |
0 |
0 |
21 |
28 |
0 |
|
4D2T
|
13 |
0 |
0 |
0 |
0 |
13 |
0 |
0 |
0 |
0 |
14 |
16 |
0 |
|
5IHA
|
19 |
10 |
0 |
0 |
0 |
3 |
0 |
0 |
0 |
0 |
21 |
23 |
0 |
|
4IXP
|
16 |
0 |
0 |
14 |
0 |
0 |
20 |
0 |
0 |
0 |
17 |
8 |
0 |
|
4D2V
|
14 |
0 |
0 |
0 |
0 |
14 |
0 |
0 |
0 |
0 |
21 |
18 |
0 |
|
5IHC
|
19 |
9 |
0 |
7 |
0 |
14 |
6 |
0 |
0 |
0 |
18 |
13 |
0 |
|
4BKZ
|
17 |
0 |
0 |
15 |
0 |
0 |
0 |
3 |
0 |
0 |
23 |
9 |
0 |
|
5IH8
|
13 |
9 |
0 |
0 |
0 |
6 |
0 |
8 |
0 |
0 |
13 |
23 |
0 |
|
4UMU
|
12 |
8 |
0 |
0 |
0 |
10 |
20 |
0 |
0 |
8 |
15 |
18 |
0 |