Q16512

Background

Protein Name
Serine/threonine-protein kinase N1
Gene Name
PKN1
Organism
Homo sapiens

Annotations

Function
PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser-159', 'Ser-163' and 'Ser-170' of MARCKS, and GFAP. Able to phosphorylate RPS6 in vitro.

Mapping Statistics

Site Maximum Consensus Site Population Minimum Consensus Site Population Median Consensus Site Population
MPP 13 5 13.0
DFG 10 1 2.0
DRS 19 14 17.0
EDI 16 14 15.0
MT3 12 12 12.0
AAS 10 2 8.0
PDIG 13 8 10.5
ATP 29 3 14.0

Mapping Results

PDB ID Maximum Consensus Site Population
MPP site DFG site PIF site DRS site DEF site EDI site MT3 site AAS site LBP site CMP site PDIG site ATP site PMP site
Total Druggable Structures per Site 0 0 0 4 0 1 0 0 0 0 0 4 0
4OTG 13 10 0 19 0 16 0 0 0 0 13 22 0
4OTD 13 0 0 17 0 14 0 0 0 0 8 20 0
4OTI 0 1 0 17 0 0 0 9 0 0 0 17 0
4OTH 5 0 0 17 0 0 12 10 0 0 0 29 0