- Protein Name
- Mitogen-activated protein kinase 6
- Gene Name
- MAPK6
- Organism
-
Homo sapiens
- Function
- Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle (By similarity).
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MPP |
8 |
4 |
6.0 |
| DFG |
11 |
11 |
11.0 |
| DRS |
4 |
4 |
4.0 |
| DEF |
14 |
12 |
13.0 |
| EDI |
19 |
4 |
6.5 |
| MT3 |
18 |
18 |
18.0 |
| AAS |
10 |
10 |
10.0 |
| PDIG |
15 |
3 |
10.0 |
| ATP |
14 |
14 |
14.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
0 |
0 |
0 |
0 |
0 |
1 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
|
2I6L
|
8 |
0 |
0 |
4 |
14 |
19 |
18 |
10 |
0 |
0 |
15 |
14 |
0 |
|
AFQ16659
|
0 |
11 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |