- Protein Name
- Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
- Gene Name
- PHKG1
- Organism
-
Homo sapiens
- Function
- Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. In vitro, phosphorylates PYGM, TNNI3, MAPT/TAU, GAP43 and NRGN/RC3 (By similarity). {ECO:0000250}.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| DFG |
28 |
28 |
28.0 |
| PDIG |
18 |
18 |
18.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
AAS site |
MT3 site |
LBP site |
ATP site |
DEF site |
DFG site |
CMP site |
PMP site |
EDI site |
DRS site |
PDIG site |
PIF site |
| Total Druggable Structures per Site |
0 |
0 |
0 |
0 |
0 |
0 |
1 |
0 |
0 |
0 |
0 |
1 |
0 |
|
AFQ16816
|
0 |
0 |
0 |
0 |
0 |
0 |
28 |
0 |
0 |
0 |
0 |
18 |
0 |