- Protein Name
- O-antigen chain terminator bifunctional methyltransferase/kinase WbdD
- Gene Name
- wbdD
- Organism
-
Escherichia coli
- Function
- Regulates the length of the LPS O-antigen polysaccharide chain. Stops the polymerization of the chain by phosphorylating and then methylating the phosphate on the terminal sugar. This terminal modification is essential for export of the O-antigen across the inner membrane. WbdD is also required for correct localization of the WbdA mannosyltransferase.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| DFG |
16 |
4 |
10.0 |
| PIF |
4 |
2 |
3.0 |
| MT3 |
7 |
3 |
5.0 |
| AAS |
15 |
1 |
10.0 |
| CMP |
10 |
10 |
10.0 |
| PDIG |
10 |
7 |
8.5 |
| ATP |
24 |
4 |
15.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
0 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
3 |
0 |
|
4AZV
|
0 |
13 |
2 |
0 |
0 |
0 |
0 |
15 |
0 |
0 |
10 |
15 |
0 |
|
4AZT
|
0 |
16 |
3 |
0 |
0 |
0 |
3 |
5 |
0 |
10 |
7 |
24 |
0 |
|
4AZS
|
0 |
10 |
0 |
0 |
0 |
0 |
7 |
14 |
0 |
0 |
10 |
16 |
0 |
|
4AZW
|
0 |
10 |
4 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
7 |
18 |
0 |