- Protein Name
- Mitogen-activated protein kinase kinase kinase MLK4
- Gene Name
- MLK4
- Organism
-
Homo sapiens
- Function
- Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MT3 |
13 |
3 |
8.0 |
| ATP |
15 |
15 |
15.0 |
| MPP |
6 |
6 |
6.0 |
| DFG |
17 |
17 |
17.0 |
| CMP |
2 |
2 |
2.0 |
| PDIG |
3 |
3 |
3.0 |
| PDB ID |
Maximum Consensus Site Population |
| EDI site |
MT3 site |
PIF site |
ATP site |
DEF site |
DRS site |
AAS site |
MPP site |
DFG site |
LBP site |
CMP site |
PDIG site |
PMP site |
| Total Druggable Structures per Site |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
1 |
0 |
0 |
0 |
0 |
|
AFQ5TCX8
|
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
17 |
0 |
0 |
0 |
0 |
|
4UYA
|
0 |
13 |
0 |
15 |
0 |
0 |
0 |
6 |
0 |
0 |
2 |
3 |
0 |