- Protein Name
- Tau-tubulin kinase 1
- Gene Name
- TTBK1
- Organism
-
Homo sapiens
- Function
- Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| PIF |
14 |
4 |
9.0 |
| DRS |
6 |
2 |
2.0 |
| EDI |
18 |
1 |
7.5 |
| MT3 |
30 |
4 |
22.0 |
| LBP |
25 |
2 |
3.0 |
| CMP |
12 |
6 |
9.0 |
| PDIG |
16 |
9 |
12.5 |
| ATP |
17 |
1 |
9.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
0 |
0 |
0 |
0 |
0 |
1 |
5 |
0 |
1 |
0 |
1 |
1 |
0 |
|
4NFN
|
0 |
0 |
9 |
0 |
0 |
11 |
30 |
0 |
11 |
12 |
0 |
15 |
0 |
|
4NFM
|
0 |
0 |
0 |
0 |
0 |
18 |
19 |
0 |
2 |
6 |
9 |
17 |
0 |
|
4BTJ
|
0 |
0 |
12 |
6 |
0 |
0 |
29 |
0 |
25 |
0 |
15 |
2 |
0 |
|
4BTK
|
0 |
0 |
14 |
0 |
0 |
6 |
24 |
0 |
0 |
0 |
10 |
1 |
0 |
|
AFQ5TCY1
|
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
4BTM
|
0 |
0 |
6 |
2 |
0 |
9 |
23 |
0 |
2 |
0 |
16 |
9 |
0 |