- Protein Name
- Serine/threonine-protein kinase BRSK2
- Gene Name
- Brsk2
- Organism
-
Mus musculus
- Function
- Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-504' and 'Ser-554'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis. Plays a role in the regulation of insulin secretion in response to elevated glucose levels, probably via phosphorylation of CDK16 and PAK1. While BRSK2 phosphorylated at Thr-175 can inhibit insulin secretion (PubMed:22798068), BRSK2 phosphorylated at Thr-261 can promote insulin secretion (PubMed:22669945). Regulates reorganization of the actin cytoskeleton. May play a role in the apoptotic response triggered by endoplasmatic reticulum (ER) stress.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MPP |
4 |
4 |
4.0 |
| DRS |
17 |
17 |
17.0 |
| EDI |
29 |
17 |
23.0 |
| MT3 |
22 |
5 |
12.5 |
| PDIG |
21 |
16 |
18.5 |
| ATP |
3 |
3 |
3.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
0 |
0 |
0 |
1 |
0 |
2 |
2 |
0 |
0 |
0 |
2 |
0 |
0 |
|
4YNZ
|
4 |
0 |
0 |
17 |
0 |
29 |
22 |
0 |
0 |
0 |
16 |
3 |
0 |
|
4YOM
|
0 |
0 |
0 |
0 |
0 |
17 |
18 |
0 |
0 |
0 |
21 |
0 |
0 |