- Protein Name
- Kinase suppressor of Ras 2
- Gene Name
- KSR2
- Organism
-
Homo sapiens
- Function
- Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MPP |
26 |
9 |
21.0 |
| DRS |
9 |
9 |
9.0 |
| MT3 |
17 |
2 |
15.5 |
| AAS |
19 |
19 |
19.0 |
| CMP |
18 |
3 |
12.0 |
| PDIG |
13 |
4 |
8.5 |
| ATP |
10 |
10 |
10.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
2 |
0 |
0 |
0 |
0 |
0 |
2 |
1 |
0 |
1 |
0 |
0 |
0 |
|
5KKR
|
21 |
0 |
0 |
9 |
0 |
0 |
17 |
19 |
0 |
18 |
4 |
10 |
0 |
|
2Y4I
|
26 |
0 |
0 |
0 |
0 |
0 |
16 |
0 |
0 |
12 |
13 |
0 |
0 |