- Protein Name
- Serine/threonine-protein kinase Nek10 {ECO:0000305}
- Gene Name
- NEK10
- Organism
-
Homo sapiens
- Function
- Plays a role in the cellular response to UV irradiation. Mediates G2/M cell cycle arrest, MEK autoactivation and ERK1/2- signaling pathway activation in response to UV irradiation. In ciliated cells of airways, it is involved in the regulation of mucociliary transport (PubMed:31959991). {ECO:0000269|PubMed:20956560, ECO:0000269|PubMed:31959991}.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| DFG |
21 |
21 |
21.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
AAS site |
MT3 site |
LBP site |
ATP site |
DEF site |
DFG site |
CMP site |
PMP site |
EDI site |
DRS site |
PDIG site |
PIF site |
| Total Druggable Structures per Site |
0 |
0 |
0 |
0 |
0 |
0 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
|
AFQ6ZWH5
|
0 |
0 |
0 |
0 |
0 |
0 |
21 |
0 |
0 |
0 |
0 |
0 |
0 |