- Protein Name
- STE20-related kinase adapter protein alpha
- Gene Name
- STRADA
- Organism
-
Homo sapiens
- Function
- Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| DFG |
26 |
7 |
14.0 |
| PIF |
15 |
6 |
12.0 |
| DRS |
16 |
2 |
11.0 |
| MT3 |
18 |
4 |
10.0 |
| CMP |
23 |
4 |
17.0 |
| ATP |
15 |
1 |
10.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
0 |
1 |
0 |
1 |
0 |
0 |
1 |
0 |
0 |
2 |
0 |
0 |
0 |
|
AFQ7RTN6
|
0 |
26 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
3GNI
|
0 |
14 |
12 |
12 |
0 |
0 |
18 |
0 |
0 |
17 |
0 |
12 |
0 |
|
2WTK
|
0 |
14 |
15 |
16 |
0 |
0 |
13 |
0 |
0 |
23 |
0 |
15 |
0 |