- Function
- Calcium-dependent kinase that plays a central role in the sexual reproduction and mosquito transmission of P.falciparum. Required for cell cycle progression in the male gametocyte, an essential step in parasite transmission to the mosquito (By similarity).
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| EDI |
15 |
14 |
14.5 |
| MT3 |
12 |
2 |
7.0 |
| ATP |
17 |
2 |
9.0 |
| DRS |
11 |
4 |
7.5 |
| MPP |
5 |
3 |
4.0 |
| LBP |
3 |
3 |
3.0 |
| PDIG |
15 |
15 |
15.0 |
| PDB ID |
Maximum Consensus Site Population |
| EDI site |
MT3 site |
PIF site |
ATP site |
DEF site |
DRS site |
AAS site |
MPP site |
DFG site |
LBP site |
CMP site |
PDIG site |
PMP site |
| Total Druggable Structures per Site |
0 |
0 |
0 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
4RGJ
|
14 |
12 |
0 |
10 |
0 |
0 |
0 |
5 |
0 |
3 |
0 |
15 |
0 |
|
4QOX
|
15 |
2 |
0 |
17 |
0 |
11 |
0 |
3 |
0 |
0 |
0 |
15 |
0 |