- Protein Name
- Calcium/calmodulin-dependent protein kinase type 1D
- Gene Name
- CAMK1D
- Organism
-
Homo sapiens
- Function
- Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MPP |
4 |
3 |
3.5 |
| AAS |
12 |
9 |
10.5 |
| MT3 |
22 |
4 |
13.0 |
| ATP |
5 |
4 |
4.5 |
| CMP |
15 |
9 |
12.0 |
| EDI |
16 |
7 |
16.0 |
| DRS |
4 |
3 |
3.5 |
| PDIG |
12 |
11 |
11.5 |
| PIF |
17 |
3 |
5.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
AAS site |
MT3 site |
LBP site |
ATP site |
DEF site |
DFG site |
CMP site |
PMP site |
EDI site |
DRS site |
PDIG site |
PIF site |
| Total Druggable Structures per Site |
0 |
0 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
1 |
0 |
0 |
1 |
|
2JC6
|
4 |
12 |
22 |
0 |
5 |
0 |
0 |
12 |
0 |
16 |
4 |
12 |
17 |
|
AFQ8IU85
|
0 |
0 |
0 |
0 |
0 |
0 |
0 |
15 |
0 |
0 |
0 |
0 |
0 |