- Protein Name
- Inactive serine/threonine-protein kinase VRK3
- Gene Name
- VRK3
- Organism
-
Homo sapiens
- Function
- Inactive kinase that suppresses ERK activity by promoting phosphatase activity of DUSP3 which specifically dephosphorylates and inactivates ERK in the nucleus.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MT3 |
2 |
2 |
2.0 |
| ATP |
6 |
6 |
6.0 |
| DFG |
11 |
11 |
11.0 |
| CMP |
8 |
8 |
8.0 |
| DRS |
11 |
2 |
5.5 |
| PDIG |
2 |
2 |
2.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
AAS site |
MT3 site |
LBP site |
ATP site |
DEF site |
DFG site |
CMP site |
PMP site |
EDI site |
DRS site |
PDIG site |
PIF site |
| Total Druggable Structures per Site |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
2JII
|
0 |
0 |
2 |
0 |
6 |
0 |
11 |
8 |
0 |
0 |
11 |
2 |
0 |