- Protein Name
- Mixed lineage kinase domain-like protein
- Gene Name
- MLKL
- Organism
-
Homo sapiens
- Function
- Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| DFG |
13 |
11 |
12.0 |
| AAS |
10 |
6 |
10.0 |
| CMP |
4 |
4 |
4.0 |
| ATP |
19 |
5 |
14.5 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
1 |
0 |
|
4M67
|
0 |
11 |
0 |
0 |
0 |
0 |
0 |
10 |
0 |
4 |
0 |
19 |
0 |
|
4MWI
|
0 |
13 |
0 |
0 |
0 |
0 |
0 |
10 |
0 |
0 |
0 |
15 |
0 |