- Protein Name
- Serine/threonine-protein kinase Nek7
- Gene Name
- NEK7
- Organism
-
Homo sapiens
- Function
- Protein kinase which plays an important role in mitotic cell cycle progression. Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis. Phosphorylates RPS6KB1.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MPP |
16 |
2 |
6.0 |
| AAS |
22 |
5 |
12.0 |
| MT3 |
2 |
2 |
2.0 |
| ATP |
17 |
3 |
16.0 |
| DFG |
19 |
19 |
19.0 |
| DRS |
13 |
6 |
8.0 |
| PDIG |
9 |
8 |
8.5 |
| PIF |
2 |
2 |
2.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
AAS site |
MT3 site |
LBP site |
ATP site |
DEF site |
DFG site |
CMP site |
PMP site |
EDI site |
DRS site |
PDIG site |
PIF site |
| Total Druggable Structures per Site |
1 |
2 |
0 |
0 |
3 |
0 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
|
AFQ8TDX7
|
16 |
0 |
0 |
0 |
0 |
0 |
19 |
0 |
0 |
0 |
0 |
0 |
0 |
|
2WQM
|
7 |
20 |
0 |
0 |
17 |
0 |
0 |
0 |
0 |
0 |
8 |
8 |
0 |
|
2WQN
|
0 |
14 |
0 |
0 |
17 |
0 |
0 |
0 |
0 |
0 |
13 |
9 |
2 |
|
5DE2
|
6 |
22 |
2 |
0 |
16 |
0 |
0 |
0 |
0 |
0 |
6 |
0 |
0 |