- Protein Name
- Serine/threonine-protein kinase haspin
- Gene Name
- GSG2
- Organism
-
Homo sapiens
- Function
- Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. This positions and activates AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| AAS |
9 |
9 |
9.0 |
| MT3 |
19 |
3 |
11.0 |
| LBP |
20 |
5 |
12.0 |
| ATP |
29 |
1 |
10.5 |
| DFG |
24 |
8 |
10.0 |
| CMP |
15 |
9 |
10.0 |
| PIF |
19 |
12 |
16.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
AAS site |
MT3 site |
LBP site |
ATP site |
DEF site |
DFG site |
CMP site |
PMP site |
EDI site |
DRS site |
PDIG site |
PIF site |
| Total Druggable Structures per Site |
0 |
0 |
3 |
3 |
9 |
0 |
2 |
0 |
0 |
0 |
0 |
0 |
6 |
|
3F2N
|
0 |
0 |
16 |
0 |
15 |
0 |
0 |
9 |
0 |
0 |
0 |
0 |
16 |
|
AFQ8TF76
|
0 |
0 |
0 |
0 |
0 |
0 |
24 |
0 |
0 |
0 |
0 |
0 |
0 |
|
3E7V
|
0 |
0 |
11 |
18 |
16 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
12 |
|
3FMD
|
0 |
0 |
0 |
5 |
16 |
0 |
8 |
0 |
0 |
0 |
0 |
0 |
0 |
|
4QTC
|
0 |
0 |
0 |
0 |
27 |
0 |
10 |
10 |
0 |
0 |
0 |
0 |
17 |
|
5HTB
|
0 |
0 |
15 |
17 |
29 |
0 |
0 |
15 |
0 |
0 |
0 |
0 |
16 |
|
4OUC
|
0 |
0 |
19 |
7 |
29 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
3IQ7
|
0 |
0 |
9 |
0 |
19 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
13 |
|
5HTC
|
0 |
0 |
9 |
12 |
27 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
17 |
|
2WB8
|
0 |
9 |
0 |
0 |
15 |
0 |
10 |
0 |
0 |
0 |
0 |
0 |
0 |
|
3DLZ
|
0 |
0 |
19 |
5 |
27 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
19 |
|
2VUW
|
0 |
0 |
0 |
20 |
29 |
0 |
22 |
0 |
0 |
0 |
0 |
0 |
16 |