- Protein Name
- Death-associated protein kinase 2
- Gene Name
- Dapk2
- Organism
-
Mus musculus
- Function
- Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Capable of regulating both type I apoptotic and type II autophagic cell death signals. The former involves caspase activation, chromatin and mitochondrial condensation while the latter involves caspase-independent cell death in conjunction with accumulation of mature autophagic vesicles, plasma membrane blebs, and nuclear condensation without DNA degradation. Mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation (By similarity). Regulates granulocytes motility by controlling cell spreading and polarization (PubMed:24163421).
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| DFG |
7 |
2 |
3.5 |
| PIF |
24 |
7 |
17.0 |
| EDI |
12 |
7 |
10.0 |
| MT3 |
20 |
3 |
5.0 |
| AAS |
11 |
11 |
11.0 |
| PDIG |
14 |
4 |
9.0 |
| ATP |
15 |
4 |
9.5 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
0 |
0 |
3 |
0 |
0 |
0 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
|
2YAA
|
0 |
4 |
16 |
0 |
0 |
11 |
8 |
0 |
0 |
0 |
14 |
15 |
0 |
|
AFQ8VDF3
|
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
2YAB
|
0 |
7 |
24 |
0 |
0 |
10 |
15 |
11 |
0 |
0 |
0 |
13 |
0 |
|
2YA9
|
0 |
2 |
19 |
0 |
0 |
12 |
20 |
0 |
0 |
0 |
0 |
9 |
0 |