- Protein Name
- CBL-interacting serine/threonine-protein kinase 23
- Gene Name
- CIPK23
- Organism
-
Arabidopsis thaliana
- Function
- CIPK serine-threonine protein kinases interact with CBL proteins. Binding of a CBL protein to the regulatory NAF domain of CIPK protein leads to activation of the kinase in a calcium-dependent manner. Downstream of CBL1, CBL2, CBL3 and CBL9, regulates by phosphorylation the K(+) conductance and uptake of AKT1 in low K(+) condition, in response to calcium signaling and during the stomatal opening regulation by monitoring the turgor pressure in guard cells. In response to low nitrate concentration, phosphorylates NRT1.1, switching it from a low-affinity nitrate transporter to a high-affinity transporter. Confers tolerance to low potassium conditions. Involved in drought sensitivity and leaf transpiration.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MT3 |
16 |
15 |
16.0 |
| PDIG |
19 |
7 |
13.0 |
| ATP |
21 |
12 |
16.5 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
0 |
0 |
0 |
0 |
0 |
0 |
2 |
0 |
0 |
0 |
1 |
1 |
0 |
|
4CZT
|
0 |
0 |
0 |
0 |
0 |
0 |
16 |
0 |
0 |
0 |
13 |
12 |
0 |
|
4CZU
|
0 |
0 |
0 |
0 |
0 |
0 |
16 |
0 |
0 |
0 |
19 |
21 |
0 |
|
AFQ93VD3
|
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |