- Function
- Activator of the abscisic acid (ABA) signaling pathway that regulates numerous ABA responses, such as stomata closure in response to drought, plant pathogens, or decreases in atmospheric relative humidity (RH). Involved in the resistance to drought by avoiding water loss. Required for the stomata closure mediated by pathogen-associated molecular pattern (PAMPs) (e.g. flg22 and LPS) of pathogenic bacteria such as P.syringae pv. tomato (Pst) and E.coli O157:H7. As a plant defense process, stomata are closed transiently in order to limit invaders, but actively reopened by bacteria after a few hours; virulent strains (e.g. Pst DC3000) are more efficient than avirulent strains (e.g. Pst DC3000 AvrRpt2) in reopening stomata. Mediates the phosphorylation and activation of the S-type anion efflux channel SLAC1, and thus promotes stomata closure. Essential for stomatal closure in response to reactive oxygen species (ROS).
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MPP |
10 |
2 |
3.0 |
| DFG |
11 |
11 |
11.0 |
| DRS |
6 |
6 |
6.0 |
| EDI |
7 |
2 |
6.0 |
| MT3 |
23 |
1 |
8.0 |
| AAS |
37 |
6 |
19.5 |
| PDIG |
5 |
5 |
5.0 |
| ATP |
16 |
2 |
8.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
0 |
0 |
0 |
0 |
0 |
0 |
4 |
4 |
0 |
0 |
0 |
1 |
0 |
|
3UJG
|
0 |
0 |
0 |
0 |
0 |
0 |
1 |
14 |
0 |
0 |
0 |
15 |
0 |
|
3UC4
|
4 |
0 |
0 |
0 |
0 |
0 |
20 |
30 |
0 |
0 |
0 |
16 |
0 |
|
3ZUU
|
3 |
0 |
0 |
0 |
0 |
0 |
19 |
24 |
0 |
0 |
0 |
8 |
0 |
|
3ZUT
|
3 |
0 |
0 |
0 |
0 |
0 |
19 |
27 |
0 |
0 |
0 |
7 |
0 |
|
3UDB
|
10 |
11 |
0 |
6 |
0 |
7 |
23 |
37 |
0 |
0 |
5 |
10 |
0 |