- Protein Name
- BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1
- Gene Name
- BAK1
- Organism
-
Arabidopsis thaliana
- Function
- Dual specificity kinase acting on both serine/threonine- and tyrosine-containing substrates. Controls the expression of genes associated with innate immunity in the absence of pathogens or elicitors. Involved in brassinosteroid (BR) signal transduction. Phosphorylates BRI1. May be involved in changing the equilibrium between plasma membrane-located BRI1 homodimers and endocytosed BRI1-BAK1 heterodimers. Interaction with MSBP1 stimulates the endocytosis of BAK1 and suppresses brassinosteroid signaling. Acts in pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI) via its interactions with FLS2 and EFR, and the phosphorylation of BIK1. Involved in programmed cell death (PCD) control. Positively regulates the BR-dependent plant growth pathway and negatively regulates the BR-independent cell-death pathway (PubMed:17583510, PubMed:17600708, PubMed:18667726, PubMed:18694562, PubMed:19124768, PubMed:20018402, PubMed:20404519, PubMed:21350342, PubMed:21693696). Phosphorylates BIR2 and thus promotes interaction with BIR2 (PubMed:24388849, PubMed:24556575). This interaction prevents interaction with FLS2 in the absence of pathogen-associated molecular patterns (PAMP) (PubMed:24388849, PubMed:24556575). Required for PSK promotion of seedling growth and protoplast expansion (PubMed:26071421). CNGC17 and AHAs form a functional cation-translocating unit that is activated by PSKR1/BAK1 and possibly other BAK1/RLK complexes (PubMed:26071421).
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MPP |
15 |
4 |
9.5 |
| DFG |
15 |
9 |
12.0 |
| PIF |
3 |
3 |
3.0 |
| MT3 |
25 |
2 |
23.0 |
| AAS |
24 |
3 |
18.0 |
| ATP |
25 |
5 |
16.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
0 |
0 |
0 |
0 |
0 |
0 |
2 |
3 |
0 |
0 |
0 |
3 |
0 |
|
3TL8
|
15 |
0 |
3 |
0 |
0 |
0 |
25 |
24 |
0 |
0 |
0 |
25 |
0 |
|
3ULZ
|
0 |
15 |
0 |
0 |
0 |
0 |
0 |
23 |
0 |
0 |
0 |
16 |
0 |
|
3UIM
|
4 |
9 |
0 |
0 |
0 |
0 |
22 |
21 |
0 |
0 |
0 |
16 |
0 |
|
AFQ94F62
|
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |