- Protein Name
- Serine/threonine-protein kinase Nek1
- Gene Name
- NEK1
- Organism
-
Homo sapiens
- Function
- Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity. Implicated in the control of meiosis (By similarity). Involved in cilium assembly. In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MPP |
5 |
2 |
4.0 |
| EDI |
9 |
9 |
9.0 |
| MT3 |
10 |
2 |
6.0 |
| AAS |
11 |
3 |
5.0 |
| PDIG |
12 |
3 |
10.0 |
| ATP |
7 |
7 |
7.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
4APC
|
5 |
0 |
0 |
0 |
0 |
0 |
2 |
9 |
0 |
0 |
10 |
0 |
0 |
|
4B9D
|
5 |
0 |
0 |
0 |
0 |
9 |
10 |
11 |
0 |
0 |
12 |
7 |
0 |