- Protein Name
- PAS domain-containing serine/threonine-protein kinase
- Gene Name
- PASK
- Organism
-
Homo sapiens
- Function
- Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate to respiratory regulation.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| DFG |
6 |
6 |
6.0 |
| DRS |
18 |
4 |
12.0 |
| MT3 |
2 |
2 |
2.0 |
| AAS |
15 |
2 |
8.5 |
| LBP |
15 |
2 |
6.0 |
| CMP |
23 |
9 |
12.0 |
| PDIG |
16 |
5 |
7.5 |
| ATP |
9 |
3 |
8.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
0 |
0 |
0 |
1 |
0 |
0 |
0 |
0 |
0 |
1 |
1 |
0 |
0 |
|
3DLS
|
0 |
6 |
0 |
18 |
0 |
0 |
2 |
15 |
15 |
23 |
16 |
9 |
0 |