- Protein Name
- Calcium/calmodulin-dependent protein kinase kinase 2
- Gene Name
- CAMKK2
- Organism
-
Homo sapiens
- Function
- Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MT3 |
2 |
2 |
2.0 |
| ATP |
8 |
4 |
6.0 |
| DFG |
23 |
12 |
17.5 |
| EDI |
14 |
14 |
14.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
AAS site |
MT3 site |
LBP site |
ATP site |
DEF site |
DFG site |
CMP site |
PMP site |
EDI site |
DRS site |
PDIG site |
PIF site |
| Total Druggable Structures per Site |
0 |
0 |
0 |
0 |
0 |
0 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
|
AFQ96RR4
|
0 |
0 |
0 |
0 |
0 |
0 |
23 |
0 |
0 |
0 |
0 |
0 |
0 |
|
2ZV2
|
0 |
0 |
2 |
0 |
8 |
0 |
12 |
0 |
0 |
14 |
0 |
0 |
0 |