- Protein Name
- Mitogen-activated protein kinase kinase kinase 14
- Gene Name
- MAP3K14
- Organism
-
Homo sapiens
- Function
- Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Promotes proteolytic processing of NFKB2/P100, which leads to activation of NF-kappa-B via the non-canonical pathway. Could act in a receptor-selective manner.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MPP |
24 |
9 |
17.5 |
| PIF |
16 |
10 |
14.0 |
| EDI |
6 |
6 |
6.0 |
| MT3 |
25 |
9 |
18.5 |
| AAS |
18 |
9 |
16.0 |
| CMP |
16 |
16 |
16.0 |
| PDIG |
9 |
5 |
5.0 |
| ATP |
16 |
2 |
3.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
4 |
0 |
4 |
0 |
0 |
0 |
3 |
2 |
0 |
1 |
0 |
1 |
0 |
|
4IDV
|
18 |
0 |
16 |
0 |
0 |
0 |
21 |
0 |
0 |
0 |
0 |
15 |
0 |
|
4IDT
|
17 |
0 |
16 |
0 |
0 |
0 |
22 |
10 |
0 |
0 |
9 |
4 |
0 |
|
4G3D
|
24 |
0 |
16 |
0 |
0 |
6 |
25 |
18 |
0 |
16 |
0 |
16 |
0 |
|
4DN5
|
18 |
0 |
16 |
0 |
0 |
0 |
11 |
16 |
0 |
0 |
0 |
2 |
0 |