- Protein Name
- Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
- Gene Name
- PKMYT1
- Organism
-
Homo sapiens
- Function
- Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| PIF |
16 |
16 |
16.0 |
| CMP |
12 |
12 |
12.0 |
| PDIG |
7 |
7 |
7.0 |
| ATP |
20 |
20 |
20.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
0 |
0 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
1 |
0 |
|
3P1A
|
0 |
0 |
16 |
0 |
0 |
0 |
0 |
0 |
0 |
12 |
7 |
20 |
0 |