- Protein Name
- Serine/threonine-protein kinase VRK1
- Gene Name
- VRK1
- Organism
-
Homo sapiens
- Function
- Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosphorylates ATF2 which activates its transcriptional activity.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MPP |
24 |
1 |
15.0 |
| AAS |
12 |
4 |
9.0 |
| MT3 |
13 |
13 |
13.0 |
| LBP |
23 |
2 |
8.0 |
| ATP |
19 |
3 |
8.0 |
| CMP |
14 |
9 |
11.0 |
| EDI |
2 |
2 |
2.0 |
| DRS |
30 |
4 |
17.0 |
| PDIG |
8 |
2 |
3.0 |
| PIF |
18 |
13 |
18.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
AAS site |
MT3 site |
LBP site |
ATP site |
DEF site |
DFG site |
CMP site |
PMP site |
EDI site |
DRS site |
PDIG site |
PIF site |
| Total Druggable Structures per Site |
1 |
0 |
0 |
1 |
1 |
0 |
0 |
0 |
0 |
0 |
1 |
0 |
2 |
|
2LAV
|
15 |
11 |
0 |
3 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
2KTY
|
0 |
0 |
0 |
14 |
3 |
0 |
0 |
10 |
0 |
0 |
4 |
0 |
0 |
|
3OP5
|
24 |
4 |
0 |
10 |
19 |
0 |
0 |
13 |
0 |
2 |
30 |
3 |
18 |
|
2KUL
|
0 |
0 |
13 |
23 |
0 |
0 |
0 |
14 |
0 |
0 |
0 |
0 |
18 |
|
2RSV
|
0 |
12 |
0 |
0 |
13 |
0 |
0 |
0 |
0 |
0 |
0 |
8 |
13 |
|
AFQ99986
|
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |