- Protein Name
- MAP kinase-interacting serine/threonine-protein kinase 1
- Gene Name
- MKNK1
- Organism
-
Homo sapiens
- Function
- May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MPP |
11 |
3 |
7.0 |
| DFG |
17 |
7 |
15.0 |
| PIF |
8 |
3 |
5.5 |
| MT3 |
10 |
10 |
10.0 |
| AAS |
17 |
3 |
10.0 |
| CMP |
21 |
21 |
21.0 |
| PDIG |
11 |
7 |
9.0 |
| ATP |
10 |
4 |
6.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
0 |
1 |
0 |
0 |
0 |
0 |
0 |
1 |
0 |
1 |
0 |
0 |
0 |
|
2HW6
|
11 |
7 |
8 |
0 |
0 |
0 |
10 |
17 |
0 |
0 |
11 |
10 |
0 |
|
AFQ9BUB5
|
0 |
17 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
21 |
0 |
0 |
0 |