- Protein Name
- Endoribonuclease
- Gene Name
- Ern1
- Organism
-
Mus musculus
- Function
- Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| EDI |
17 |
10 |
12.0 |
| MT3 |
31 |
3 |
7.5 |
| ATP |
19 |
7 |
9.0 |
| CMP |
23 |
3 |
6.5 |
| PDIG |
16 |
6 |
11.0 |
| PDB ID |
Maximum Consensus Site Population |
| EDI site |
MT3 site |
PIF site |
ATP site |
DEF site |
DRS site |
AAS site |
MPP site |
DFG site |
LBP site |
CMP site |
PDIG site |
PMP site |
| Total Druggable Structures per Site |
1 |
3 |
0 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
1 |
1 |
0 |
|
4PL3
|
10 |
31 |
0 |
7 |
0 |
0 |
0 |
0 |
0 |
0 |
3 |
16 |
0 |
|
4PL5
|
17 |
17 |
0 |
19 |
0 |
0 |
0 |
0 |
0 |
0 |
4 |
6 |
0 |
|
4PL4
|
12 |
28 |
0 |
9 |
0 |
0 |
0 |
0 |
0 |
0 |
23 |
0 |
0 |
|
AFQ9EQY0
|
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |