- Protein Name
- MAP kinase-interacting serine/threonine-protein kinase 2
- Gene Name
- MKNK2
- Organism
-
Homo sapiens
- Function
- Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| DFG |
27 |
27 |
27.0 |
| MT3 |
10 |
4 |
5.5 |
| AAS |
22 |
3 |
16.0 |
| PDIG |
13 |
6 |
10.0 |
| ATP |
19 |
5 |
12.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
0 |
1 |
0 |
0 |
0 |
0 |
0 |
3 |
0 |
0 |
0 |
1 |
0 |
|
2AC5
|
0 |
0 |
0 |
0 |
0 |
0 |
6 |
22 |
0 |
0 |
6 |
15 |
0 |
|
2HW7
|
0 |
0 |
0 |
0 |
0 |
0 |
9 |
17 |
0 |
0 |
10 |
12 |
0 |
|
AFQ9HBH9
|
0 |
27 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
2AC3
|
0 |
0 |
0 |
0 |
0 |
0 |
10 |
21 |
0 |
0 |
13 |
19 |
0 |