Q9JIH7

Background

Protein Name
Serine/threonine-protein kinase WNK1
Gene Name
Wnk1
Organism
Rattus norvegicus

Annotations

Function
Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D and SGK1. Controls sodium and chloride ion transport by inhibiting the activity of WNK4, by either phosphorylating the kinase or via an interaction between WNK4 and the autoinhibitory domain of WNK1. WNK4 regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation. WNK1 may also play a role in actin cytoskeletal reorganization. Phosphorylates NEDD4L. Acts as a scaffold to inhibit SLC4A4, SLC26A6 as well as CFTR activities and surface expression, recruits STK39 which mediates the inhibition (By similarity). Isoform 5: Dominant-negative regulator of the longer isoform 1. Does not have kinase acitivity, does not directly inhibit WNK4 and has no direct effect on sodium and chloride ion transport. Downregulates sodium-chloride cotransporter activity indirectly by inhibiting isoform 1, it associates with isoform 1 and attenuates its kinase activity. In kidney, may play an important role regulating sodium and potassium balance.

Mapping Statistics

Site Maximum Consensus Site Population Minimum Consensus Site Population Median Consensus Site Population
PIF 2 2 2.0
DRS 4 4 4.0
MT3 17 2 13.0
AAS 11 5 8.0
CMP 20 8 11.0
PDIG 4 2 3.0
ATP 14 14 14.0

Mapping Results

PDB ID Maximum Consensus Site Population
MPP site DFG site PIF site DRS site DEF site EDI site MT3 site AAS site LBP site CMP site PDIG site ATP site PMP site
Total Druggable Structures per Site 0 0 0 0 0 0 2 0 0 1 0 0 0
4Q2A 0 0 0 0 0 0 16 5 0 8 4 14 0
AFQ9JIH7 0 0 0 0 0 0 0 0 0 20 0 0 0
3FPQ 0 0 2 4 0 0 17 11 0 11 2 14 0