Q9JLS3

Background

Protein Name
Serine/threonine-protein kinase TAO2
Gene Name
Taok2
Organism
Rattus norvegicus

Annotations

Function
Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. May affect microtubule organization and stability. May play a role in the osmotic stress-MAPK8 pathway. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14/p38 MAPK activation.

Mapping Statistics

Site Maximum Consensus Site Population Minimum Consensus Site Population Median Consensus Site Population
MPP 13 4 6.0
DFG 15 3 4.5
DRS 20 2 12.0
MT3 11 3 8.0
CMP 8 6 7.0
PDIG 18 3 16.0
ATP 14 4 10.0

Mapping Results

PDB ID Maximum Consensus Site Population
MPP site DFG site PIF site DRS site DEF site EDI site MT3 site AAS site LBP site CMP site PDIG site ATP site PMP site
Total Druggable Structures per Site 0 0 0 2 0 0 0 0 0 0 3 0 0
1U5R 13 3 0 20 0 0 11 0 0 7 17 10 0
AFQ9JLS3 0 15 0 0 0 0 0 0 0 0 0 0 0
2GCD 11 6 0 16 0 0 3 0 0 0 16 14 0
1U5Q 6 3 0 15 0 0 10 0 0 8 18 4 0