- Protein Name
- CBL-interacting serine/threonine-protein kinase 24
- Gene Name
- CIPK24
- Organism
-
Arabidopsis thaliana
- Function
- Involved in the regulatory pathway for the control of intracellular Na(+) and K(+) homeostasis and salt tolerance. Activates the vacuolar H(+)/Ca(2+) antiporter CAX1 and operates in synergy with CBL4/SOS3 to activate the plasma membrane Na(+)/H(+) antiporter SOS1. CIPK serine-threonine protein kinases interact with CBL proteins. Binding of a CBL protein to the regulatory NAF domain of CIPK protein lead to the activation of the kinase in a calcium-dependent manner. Phosphorylates CBL1, CBL4 and CBL10.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MPP |
3 |
3 |
3.0 |
| DRS |
8 |
8 |
8.0 |
| EDI |
14 |
14 |
14.0 |
| MT3 |
15 |
5 |
9.0 |
| PDIG |
15 |
8 |
11.5 |
| ATP |
18 |
18 |
18.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
1 |
0 |
|
4D28
|
3 |
0 |
0 |
8 |
0 |
14 |
15 |
0 |
0 |
0 |
15 |
18 |
0 |
|
AFQ9LDI3
|
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |