- Protein Name
- Serine/threonine-protein kinase PAK 6
- Gene Name
- PAK6
- Organism
-
Homo sapiens
- Function
- Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MPP |
10 |
10 |
10.0 |
| DFG |
5 |
3 |
4.0 |
| DRS |
19 |
13 |
18.0 |
| MT3 |
17 |
11 |
16.0 |
| CMP |
14 |
12 |
13.0 |
| PDIG |
17 |
10 |
13.0 |
| ATP |
15 |
8 |
14.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
0 |
0 |
0 |
2 |
0 |
0 |
2 |
0 |
0 |
0 |
1 |
0 |
0 |
|
4KS7
|
0 |
4 |
0 |
13 |
0 |
0 |
16 |
0 |
0 |
12 |
11 |
15 |
0 |
|
4KS8
|
0 |
5 |
0 |
18 |
0 |
0 |
17 |
0 |
0 |
14 |
17 |
14 |
0 |
|
2C30
|
10 |
0 |
0 |
19 |
0 |
0 |
11 |
0 |
0 |
0 |
10 |
8 |
0 |
|
AFQ9NQU5
|
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
15 |
0 |
0 |