- Protein Name
- Cyclin-dependent kinase 12
- Gene Name
- CDK12
- Organism
-
Homo sapiens
- Function
- Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MPP |
18 |
3 |
6.0 |
| DFG |
25 |
2 |
4.0 |
| PIF |
22 |
11 |
14.0 |
| DRS |
3 |
3 |
3.0 |
| EDI |
5 |
5 |
5.0 |
| AAS |
13 |
13 |
13.0 |
| LBP |
24 |
2 |
14.0 |
| CMP |
11 |
2 |
3.0 |
| ATP |
27 |
17 |
21.5 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
1 |
1 |
2 |
0 |
0 |
0 |
0 |
0 |
2 |
0 |
0 |
4 |
0 |
|
4CXA
|
5 |
0 |
19 |
0 |
0 |
0 |
0 |
0 |
24 |
3 |
0 |
26 |
0 |
|
4UN0
|
18 |
4 |
11 |
0 |
0 |
0 |
0 |
13 |
19 |
11 |
0 |
17 |
0 |
|
5ACB
|
10 |
0 |
22 |
3 |
0 |
0 |
0 |
0 |
14 |
0 |
0 |
17 |
0 |
|
4NST
|
7 |
2 |
14 |
0 |
0 |
5 |
0 |
0 |
10 |
2 |
0 |
27 |
0 |
|
AFQ9NYV4
|
0 |
25 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |