- Protein Name
- Serine/threonine-protein kinase MARK1
- Gene Name
- MARK1
- Organism
-
Homo sapiens
- Function
- Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MPP |
25 |
19 |
22.0 |
| DFG |
3 |
3 |
3.0 |
| PIF |
7 |
7 |
7.0 |
| EDI |
16 |
7 |
13.0 |
| MT3 |
16 |
2 |
9.0 |
| AAS |
18 |
2 |
6.0 |
| LBP |
2 |
2 |
2.0 |
| PDIG |
15 |
3 |
10.0 |
| ATP |
16 |
8 |
12.0 |
| PMP |
12 |
2 |
7.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
1 |
0 |
0 |
0 |
0 |
1 |
1 |
1 |
0 |
0 |
0 |
1 |
0 |
|
AFQ9P0L2
|
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
2HAK
|
25 |
3 |
7 |
0 |
0 |
16 |
16 |
18 |
2 |
0 |
15 |
16 |
12 |