Kinase Atlas

Function: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression, the regulation of cap-dependent protein translation and through survival signaling by phosphorylation of a pro-apoptotic protein, BAD. Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase transcriptional activity. The stabilization of MYC exerted by PIM2 might explain partly the strong synergism between these 2 oncogenes in tumorigenesis. Regulates cap-dependent protein translation in a mammalian target of rapamycin complex 1 (mTORC1)-independent manner and in parallel to the PI3K-Akt pathway. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Promotes cell survival in response to a variety of proliferative signals via positive regulation of the I-kappa-B kinase/NF-kappa-B cascade; this process requires phosphorylation of MAP3K8/COT. Promotes growth factor-independent proliferation by phosphorylation of cell cycle factors such as CDKN1A and CDKN1B. Involved in the positive regulation of chondrocyte survival and autophagy in the epiphyseal growth plate.

Site	Maximum Consensus Site Population	Minimum Consensus Site Population	Median Consensus Site Population
MPP	5	5	5.0
DFG	18	10	14.0
EDI	17	2	9.5
AAS	12	12	12.0
PDIG	27	9	13.0
ATP	19	2	14.5

PDB ID	Maximum Consensus Site Population
PDB ID	MPP site	DFG site	PIF site	DRS site	DEF site	EDI site	MT3 site	AAS site	LBP site	CMP site	PDIG site	ATP site	PMP site
Total Druggable Structures per Site	0	1	0	0	0	1	0	0	0	0	1	2	0
4X7Q	0	0	0	0	0	17	0	12	0	0	14	19	0
2IWI	5	18	0	0	0	2	0	0	0	0	27	17	0

Q9P1W9