- Protein Name
- Serine/threonine-protein kinase PAK 5
- Gene Name
- PAK5
- Organism
-
Homo sapiens
- Function
- Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MPP |
17 |
6 |
12.5 |
| DFG |
8 |
8 |
8.0 |
| DRS |
23 |
22 |
22.5 |
| DEF |
7 |
4 |
5.5 |
| MT3 |
8 |
2 |
5.0 |
| PDIG |
4 |
2 |
3.0 |
| ATP |
13 |
7 |
10.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
1 |
0 |
0 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
2F57
|
17 |
8 |
0 |
23 |
7 |
0 |
8 |
0 |
0 |
0 |
4 |
13 |
0 |