- Protein Name
- Receptor-interacting serine/threonine-protein kinase 3
- Gene Name
- Ripk3
- Organism
-
Mus musculus
- Function
- Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MPP |
15 |
6 |
12.0 |
| DFG |
14 |
2 |
12.0 |
| PIF |
15 |
15 |
15.0 |
| MT3 |
20 |
6 |
13.5 |
| AAS |
19 |
18 |
18.5 |
| CMP |
22 |
14 |
20.0 |
| ATP |
18 |
5 |
11.5 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
0 |
0 |
0 |
0 |
0 |
0 |
1 |
1 |
0 |
2 |
0 |
2 |
0 |
|
4M66
|
10 |
2 |
15 |
0 |
0 |
0 |
0 |
0 |
0 |
22 |
0 |
18 |
0 |
|
4M69
|
15 |
0 |
0 |
0 |
0 |
0 |
20 |
19 |
0 |
14 |
0 |
17 |
0 |
|
AFQ9QZL0
|
0 |
14 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
20 |
0 |
0 |
0 |