- Protein Name
- Non-receptor tyrosine-protein kinase TYK2
- Gene Name
- Tyk2
- Organism
-
Mus musculus
- Function
- Involved in intracellular signal transduction by amplifying type I and type II IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain. Plays an essential role in promoting selective immune responses, including innate host defense mechanisms and specific antiviral activities.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MT3 |
21 |
9 |
10.0 |
| PIF |
17 |
17 |
17.0 |
| ATP |
8 |
8 |
8.0 |
| AAS |
12 |
12 |
12.0 |
| PDIG |
15 |
14 |
14.5 |
| PDB ID |
Maximum Consensus Site Population |
| EDI site |
MT3 site |
PIF site |
ATP site |
DEF site |
DRS site |
AAS site |
MPP site |
DFG site |
LBP site |
CMP site |
PDIG site |
PMP site |
| Total Druggable Structures per Site |
0 |
1 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
4E1Z
|
0 |
10 |
0 |
8 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
14 |
0 |
|
4E20
|
0 |
21 |
17 |
8 |
0 |
0 |
12 |
0 |
0 |
0 |
0 |
15 |
0 |