- Protein Name
- Death-associated protein kinase 2
- Gene Name
- DAPK2
- Organism
-
Homo sapiens
- Function
- Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell death signals, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Acts as a mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation (PubMed:17347302). Regulates granulocytic motility by controlling cell spreading and polarization (PubMed:24163421).
Isoform 2 is not regulated by calmodulin. It can phosphorylate MYL9. It can induce membrane blebbing and autophagic cell death.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| EDI |
16 |
2 |
11.5 |
| MT3 |
25 |
2 |
6.5 |
| PIF |
17 |
11 |
15.0 |
| ATP |
19 |
1 |
15.0 |
| MPP |
1 |
1 |
1.0 |
| DFG |
11 |
1 |
4.0 |
| CMP |
19 |
2 |
15.0 |
| PDIG |
34 |
2 |
14.0 |
| PDB ID |
Maximum Consensus Site Population |
| EDI site |
MT3 site |
PIF site |
ATP site |
DEF site |
DRS site |
AAS site |
MPP site |
DFG site |
LBP site |
CMP site |
PDIG site |
PMP site |
| Total Druggable Structures per Site |
2 |
3 |
2 |
6 |
0 |
0 |
0 |
0 |
0 |
0 |
2 |
3 |
0 |
|
1Z9X
|
16 |
18 |
0 |
16 |
0 |
0 |
0 |
0 |
9 |
0 |
0 |
18 |
0 |
|
2A27
|
16 |
25 |
17 |
17 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
8 |
0 |
|
1ZWS
|
9 |
7 |
15 |
16 |
0 |
0 |
0 |
0 |
5 |
0 |
19 |
14 |
0 |
|
1WMK
|
14 |
7 |
16 |
16 |
0 |
0 |
0 |
0 |
7 |
0 |
18 |
5 |
0 |
|
AFQ9UIK4
|
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
2CKE
|
14 |
12 |
0 |
19 |
0 |
0 |
0 |
1 |
7 |
0 |
2 |
34 |
0 |
|
2A2A
|
13 |
24 |
0 |
18 |
0 |
0 |
0 |
0 |
11 |
0 |
0 |
17 |
0 |