- Protein Name
- TRAF2 and NCK-interacting protein kinase
- Gene Name
- TNIK
- Organism
-
Homo sapiens
- Function
- Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MPP |
32 |
6 |
10.5 |
| DFG |
13 |
4 |
11.0 |
| DRS |
14 |
11 |
13.5 |
| MT3 |
22 |
4 |
11.0 |
| AAS |
22 |
7 |
13.0 |
| CMP |
16 |
8 |
12.0 |
| PDIG |
16 |
5 |
9.0 |
| ATP |
23 |
4 |
6.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
2 |
0 |
0 |
0 |
0 |
0 |
1 |
1 |
0 |
1 |
1 |
1 |
0 |
|
AFQ9UKE5
|
32 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
5AX9
|
9 |
13 |
0 |
14 |
0 |
0 |
13 |
0 |
0 |
8 |
8 |
5 |
0 |
|
5CWZ
|
12 |
11 |
0 |
14 |
0 |
0 |
0 |
11 |
0 |
16 |
5 |
4 |
0 |
|
2X7F
|
17 |
4 |
0 |
13 |
0 |
0 |
22 |
22 |
0 |
0 |
16 |
23 |
0 |