- Protein Name
- Calcium/calmodulin-dependent protein kinase type II subunit alpha
- Gene Name
- CAMK2A
- Organism
-
Homo sapiens
- Function
- CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity). Phosphorylates transcription factor FOXO3 on 'Ser-298' (PubMed:23805378). Activates FOXO3 transcriptional activity (By similarity).
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| AAS |
27 |
4 |
15.0 |
| MT3 |
29 |
16 |
22.5 |
| ATP |
17 |
3 |
14.5 |
| DFG |
8 |
8 |
8.0 |
| EDI |
11 |
6 |
8.5 |
| DRS |
11 |
2 |
7.5 |
| PIF |
16 |
4 |
5.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
AAS site |
MT3 site |
LBP site |
ATP site |
DEF site |
DFG site |
CMP site |
PMP site |
EDI site |
DRS site |
PDIG site |
PIF site |
| Total Druggable Structures per Site |
0 |
2 |
2 |
0 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
1 |
|
3SOA
|
0 |
20 |
29 |
0 |
13 |
0 |
0 |
0 |
0 |
11 |
11 |
0 |
16 |
|
2VZ6
|
0 |
27 |
16 |
0 |
17 |
0 |
8 |
0 |
0 |
6 |
10 |
0 |
5 |