- Protein Name
- Mitogen-activated protein kinase kinase kinase 14
- Gene Name
- Map3k14
- Organism
-
Mus musculus
- Function
- Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Promotes proteolytic processing of NFKB2/P100, which leads to activation of NF-kappa-B via the non-canonical pathway. Could act in a receptor-selective manner.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| MT3 |
27 |
5 |
9.0 |
| AAS |
29 |
3 |
11.5 |
| CMP |
9 |
2 |
5.0 |
| PDIG |
13 |
6 |
8.0 |
| ATP |
17 |
1 |
7.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
0 |
0 |
0 |
0 |
0 |
0 |
2 |
2 |
0 |
0 |
0 |
2 |
0 |
|
4G3E
|
0 |
0 |
0 |
0 |
0 |
0 |
27 |
29 |
0 |
5 |
0 |
6 |
0 |
|
4G3G
|
0 |
0 |
0 |
0 |
0 |
0 |
5 |
0 |
0 |
2 |
13 |
16 |
0 |
|
4G3C
|
0 |
0 |
0 |
0 |
0 |
0 |
26 |
18 |
0 |
9 |
0 |
0 |
0 |
|
4G3F
|
0 |
0 |
0 |
0 |
0 |
0 |
9 |
5 |
0 |
5 |
8 |
17 |
0 |