Kinase Atlas

Function: Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents. Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB. In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including FADD, TRADD, MAVS, AZI2, TANK or TBKBP1/SINTBAD can be recruited to the TBK1-containing-complexes. Under particular conditions, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus. Restricts bacterial proliferation by phosphorylating the autophagy receptor OPTN/Optineurin on 'Ser-177', thus enhancing LC3 binding affinity and antibacterial autophagy. Phosphorylates and activates AKT1. Seems to play a role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity.

Site	Maximum Consensus Site Population	Minimum Consensus Site Population	Median Consensus Site Population
MPP	16	10	13.0
PIF	29	9	14.0
MT3	20	10	14.0
AAS	26	6	16.0
ATP	17	2	4.0

PDB ID	Maximum Consensus Site Population
PDB ID	MPP site	DFG site	PIF site	DRS site	DEF site	EDI site	MT3 site	AAS site	LBP site	CMP site	PDIG site	ATP site	PMP site
Total Druggable Structures per Site	1	0	1	0	0	0	1	2	0	0	0	1	0
4JLC	16	0	14	0	0	0	20	17	0	0	0	17	0
4JL9	10	0	29	0	0	0	14	26	0	0	0	4	0

Q9WUN2