- Protein Name
- Serine/threonine-protein kinase MRCK beta
- Gene Name
- CDC42BPB
- Organism
-
Homo sapiens
- Function
- Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates PPP1R12A.
| Site |
Maximum Consensus Site Population |
Minimum Consensus Site Population |
Median Consensus Site Population |
| PIF |
23 |
8 |
22.0 |
| DRS |
10 |
2 |
6.5 |
| EDI |
17 |
8 |
14.0 |
| MT3 |
9 |
2 |
3.0 |
| LBP |
4 |
2 |
3.0 |
| PDIG |
29 |
7 |
22.0 |
| ATP |
17 |
2 |
14.0 |
| PDB ID |
Maximum Consensus Site Population |
| MPP site |
DFG site |
PIF site |
DRS site |
DEF site |
EDI site |
MT3 site |
AAS site |
LBP site |
CMP site |
PDIG site |
ATP site |
PMP site |
| Total Druggable Structures per Site |
0 |
0 |
2 |
0 |
0 |
1 |
0 |
0 |
0 |
0 |
3 |
1 |
0 |
|
3QFV
|
0 |
0 |
22 |
7 |
0 |
17 |
2 |
0 |
0 |
0 |
7 |
17 |
0 |
|
4UAK
|
0 |
0 |
0 |
10 |
0 |
15 |
0 |
0 |
4 |
0 |
25 |
14 |
0 |
|
3TKU
|
0 |
0 |
23 |
5 |
0 |
13 |
9 |
0 |
0 |
0 |
23 |
15 |
0 |
|
4UAL
|
0 |
0 |
0 |
10 |
0 |
14 |
0 |
0 |
2 |
0 |
29 |
14 |
0 |